https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12705 2) appears to be the major determinant of CBF and the factors determining MVo₂ (mainly developed tension and contractile state) are, therefore, major determinants of CBF. The direct effects of autonomic excitation on CBF appear relatively minor, however; the vagus, sympathetic nerves and adrenal medullary hormones profoundly alter CBF indirectly through changes in MVo₂. In the eschaemic heart with atheromatous occlusion of large vessels there is a reduced capacity for autoregulation, and nutrient flow is more dependent on pressure gradient. Hypertension and valvular disorders are often associated with raised MVo₂ but associated abnormalities in pressure gradient and resistance to flow often hinder the supply of CBF needed to meet high demands.]]> Wed 24 Jul 2013 22:24:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33112 Thu 04 Nov 2021 10:38:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43570 P=0·0002) which dissipated after further adjustment for smoking, physical activity, BMI and race (RR=0·91; 95 % CI 0·80, 1·04; P=0·27). This magnitude of association was further attenuated once we adjusted for the Alternative Healthy Eating Index excluding vegetable and fruit consumption (RR=1·04, 95 % CI 0·91, 1·20; P=0·34). Dietary nitrate intake was not related to the risk of CHD after adjustment for other lifestyle and non-vegetable dietary factors in a large group of US women.]]> Fri 23 Sep 2022 13:35:30 AEST ]]>